Pantheon SEMPARIS Le serveur des séminaires parisiens Paris

Statut Confirmé
Série MATH-IHES
Domaines hep-th
Date Jeudi 18 Janvier 2018
Heure 14:30
Institut IHES
Salle Amphithéâtre Léon Motchane
Nom de l'orateur Maitre
Prenom de l'orateur Jean-Leon
Addresse email de l'orateur
Institution de l'orateur Institut Curie, Paris
Titre Mechanics of blastocyst morphogenesis
Résumé During pre-implantation development, the mammalian embryo forms the blastocyst, which will implant into the uterus. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled cavity and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo. Using microaspiration, live-imaging, genetics and theoretical modelling, we study the biophysical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the crucial role of acto-myosin contractility, which generates periodic waves of contractions, compacts the embryo, controls the position of cells within the embryo and influences fate specification.
Numéro de preprint arXiv
Commentaires Séminaire de mathématique-Biologie
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