Pantheon SEMPARIS Le serveur des séminaires parisiens Paris

Statut Confirmé
Série MATH-IHES
Domaines hep-th
Date Mercredi 22 Novembre 2017
Heure 11:00
Institut IHES
Salle Amphithéâtre Léon Motchane
Nom de l'orateur Tosenberger
Prenom de l'orateur Alen
Addresse email de l'orateur
Institution de l'orateur Université Libre de Bruxelles & IHES
Titre Mathematical modeling of cell lineage specification in mouse embryo development
Résumé Embryonic development is a self-organized process during which cells divide, interact, change fate according to a complex gene regulatory network and organize themselves in a three-dimensional (3D) space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast (Epi) and primitive endoderm (PrE) identities within the inner cell mass (ICM) of the preimplantation embryo in the mouse. The multiscale model describes cell division and biomechanical interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix. We use the model to study the Epi and PrE lineage development and the appearance of a so-called salt-and-pepper pattern which the two lineages form.
Numéro de preprint arXiv
Commentaires
Fichiers attachés

Pour obtenir l' affiche de ce séminaire : [ Postscript | PDF ]

[ Annonces ]    [ Abonnements ]    [ Archive ]    [ Aide ]    [ ]
[ English version ]