Pantheon SEMPARIS Le serveur des séminaires parisiens Paris

Status Confirmed
Seminar Series MATH-IHES
Subjects hep-th
Date Thursday 18 January 2018
Time 14:30
Institute IHES
Seminar Room Amphithéâtre Léon Motchane
Speaker's Last Name Maitre
Speaker's First Name Jean-Leon
Speaker's Email Address
Speaker's Institution Institut Curie, Paris
Title Mechanics of blastocyst morphogenesis
Abstract During pre-implantation development, the mammalian embryo forms the blastocyst, which will implant into the uterus. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled cavity and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo. Using microaspiration, live-imaging, genetics and theoretical modelling, we study the biophysical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the crucial role of acto-myosin contractility, which generates periodic waves of contractions, compacts the embryo, controls the position of cells within the embryo and influences fate specification.
arXiv Preprint Number
Comments Séminaire de mathématique-Biologie
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