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Statut Confirmé
Série BIOPHY-ENS-ESPCI
Domaines physics.bio-ph
Date Vendredi 17 Janvier 2020
Heure 13:00
Institut DPT-PHYS-ENS
Salle Conf IV
Nom de l'orateur Aulehla
Prenom de l'orateur Alexander
Addresse email de l'orateur
Institution de l'orateur EMBL Heidelberg
Titre Arnold tongues in mouse embryos — the study of collective signalling oscillations in embryonic patterning
Résumé We study the origin and function of signaling oscillations in embryonic development. Oscillatory activities (period ~2 hours) of the Notch, Wnt and Fgf signaling pathway have been identified in mouse embryos and are linked to periodic mesoderm segmentation and the formation of pre-vertebrae, somites. Most strikingly, Notch signaling oscillations occur highly synchronized, yet phase-shifted, in cell ensembles, leading to spatio-temporal wave patterns sweeping through the embryo. I will discuss how we use general synchronisation principles based on entrainment/Arnold tongues to reveal general properties and function of collective oscillations during the mesoderm patterning process.
Numéro de preprint arXiv
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