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Statut |
Confirmé |
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Série |
BIOPHY-ENS-ESPCI |
|
Domaines |
physics.bio-ph |
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Date |
Vendredi 14 Janvier 2022 |
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Heure |
15:00 |
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Institut |
LPENS |
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Salle |
Zoom |
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Nom de l'orateur |
Hobert |
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Prenom de l'orateur |
Oliver |
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Addresse email de l'orateur |
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Institution de l'orateur |
Columbia University |
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Titre |
Gene regulatory logic of neuronal cell type diversification and neuronal circuit assembly |
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Résumé |
The enormous diversity of cell types in any animal model system is defined by
neuron type-specific gene batteries that endow distinct cells with distinct
anatomical and functional properties. Based on my laboratory’s work in
Caenorhabditis elegans as well as recent gene expression studies in vertebrates
and flies, I propose that the diversity of neuronal cell types can be reduced to a
simpler descriptor, the combinatorial expression of a specific class of
transcription factors, encoded by homeobox genes. Functional studies in multiple
animal model systems have corroborated the importance of homeobox genes in
specifying neuronal identity and perhaps also neuronal circuit assembly. I propose
that the preponderance of homeobox genes in neuronal identity control is a
reflection of an evolutionary trajectory in which an ancestral neuron type was
specified by an ancestral homeobox genes and that this functional linkage then
duplicated and diversified to generate distinct cell types and neuronal assemblies
in an evolving nervous system. |
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Numéro de preprint arXiv |
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Commentaires |
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