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Résumé |
What is the basis of learning and memory in the brain? Neurons are the main players and synapses that are micro-contact between them play a critical role. How synapses are organized at a molecular level and what defines their synaptic strength at a molecular level remains unclear, although it is due to the combine effect of many molecules together. Thus the number of receptors and molecules must be well regulated. \par I will present here an integrative modeling approach of synaptic transmission that accounts for receptor dynamics and a novel method to extract local biophysical properties from thousands of individual trajectories obtained from superresolution microscopy data. \par This talk summarizes our long lasting effort in integrating key parameters involved in regulating synaptic transmission and plasticity.\\ \\ (Will take place: ``LPTMS, bât. 100, salle 201, campus d'Orsay''; coffee and tea will be served at 14h00.) |
