Pantheon SEMPARIS Le serveur des séminaires parisiens Paris

Status Confirmed
Seminar Series MATH-IHES
Subjects hep-th
Date Wednesday 22 November 2017
Time 11:00
Institute IHES
Seminar Room Amphithéâtre Léon Motchane
Speaker's Last Name Tosenberger
Speaker's First Name Alen
Speaker's Email Address
Speaker's Institution Université Libre de Bruxelles & IHES
Title Mathematical modeling of cell lineage specification in mouse embryo development
Abstract Embryonic development is a self-organized process during which cells divide, interact, change fate according to a complex gene regulatory network and organize themselves in a three-dimensional (3D) space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast (Epi) and primitive endoderm (PrE) identities within the inner cell mass (ICM) of the preimplantation embryo in the mouse. The multiscale model describes cell division and biomechanical interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix. We use the model to study the Epi and PrE lineage development and the appearance of a so-called salt-and-pepper pattern which the two lineages form.
arXiv Preprint Number

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