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Abstract |
In living matter, a complex network of molecular cascade events involving hundreds of different molecules, which have to diffuse, meet and interact at the correct time and in the correct place is responsible for the transmission of information through cells [1,2]. All these biochemical reactions are highly spatially organized and coordinated. Beyond Brownian diffusion, the way in which the various actors of a given biochemical process, in the overcrowded cellular space, efficiently find each other over long distances is still pending. Among the forces that drives cell organization, one could rely to long-range attractive forces. In this presentation we will show that long-range electrodynamic intermolecular forces [3] between proteins can be activated under suitable experimental conditions. We will describe the activation of out-of-equilibrium collective oscillations of a macromolecule, at the origin of these forces, as a classical phonon condensation phenomenon [4,5], thus, resulting in fingerprints in the TeraHertz (THz) frequency band [6].
[1] L. Dehmelt, & PIH Bastiaens, Nat. Rev. Mol. Cell Biol. 11, 440–452 (2010).
[2] K. Venkatesan et al., Nat Methods 6, 83–90 (2009).
[3] M. Lechelon et al., Sci. Adv. 8, eabl5855 (2022)
[4] H. Froehlich, Nature, vol. 228, 1093 (1970).
[5] J. Preto et al., Phys. Rev. E 91, 052710 (2015).
[6] I. Nardecchia, et al., Phys Rev. X 031061 (2018). |
