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Résumé |
We study the origin and function of signaling oscillations in embryonic development. Oscillatory activities
(period ~2 hours) of the Notch, Wnt and Fgf signaling pathway have been identified in mouse embryos and
are linked to periodic mesoderm segmentation and the formation of pre-vertebrae, somites. Most
strikingly, Notch signaling oscillations occur highly synchronized, yet phase-shifted, in cell ensembles,
leading to spatio-temporal wave patterns sweeping through the embryo. I will discuss how we use general
synchronisation principles based on entrainment/Arnold tongues to reveal general properties and function
of collective oscillations during the mesoderm patterning process. |
