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Résumé |
Understanding how organ shape emerges and diversifies in animal remains a major
challenge in biology. While molecular signalling has been extensively studied, the
contribution of mechanical forces to morphogenesis, particularly at the interfaces
where neighbouring tissues interact, remains less undetrstood. The extracellular
matrix (ECM) often mediates the mechanical coupling between tissues and can
transmit forces across tissue boundaries, potentially influencing organ
morphogenesis and its diversification across evolution. Yet, the role of ECM-
mediated inter-tissue coupling in development and evolution remains largely
unexplored. Here, we propose to address this question using the olfactory placode
and its interaction with the neighbouring eye as a model system across different
fish species. By integrating live imaging, force and stiffness mapping, cross-
species comparisons and targeted mechanical pertubrations, we aim to dissect the
mechanism of force transmission at tissue interfaces and to determine how they
contribute to organ morphogenesis and its diversification across evolution. |
