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Résumé |
Protein localisation is essential for a wide range of biological functions.
Understanding how proteins defy the pure laws of diffusion and do not distribute
themselves homogeneously within a cell is a central question in living systems. We
report here that Ag43, an outer membrane protein responsable for cell-cell
adhesion in E. Coli, is found primarily at cell poles. To our surprise, we
discovered that Ag43 undergoes biased diffusion in the periplasm - the space
between the inner and outer membrane - driven by the oscillations of Min proteins
in the cytoplasm. This discovery could pave the way for a new paradigm explaining
the coupling of protein transport between two distinct cellular compartments
separated by a membrane. |
