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Résumé |
Biological morphogenesis produces robust yet diverse functional forms through the
interplay of biochemical regulation, cellular activity, and tissue mechanics.
In this talk, I will present my efforts on the active matter modeling that couple
mechanical, chemical and genetic cues to explain how 3D shapes emerge during
development. I will focus on three completed works: (1) the 3D chemo-mechanical
morphodynamics of cell cortex; (2) contractility-induced phase separation in
active solids, explaining periodic tracheal ring formation; and (3) genetic
regulations on growth-induced tissue buckling including divergent chick gut
surface patterns and brain foldings across species.
Time permitting, I will briefly outline my ongoing work: (1) neuromechanics of
peristalsis, (2) active chiral fluid shell model for left-right axis establishment
in C. elegans, (3) a hybrid vertex-continuum model for epithelium-extracellular
matrix (ECM) bilayer, and (4) chemomechanical vertex model for eye disk ommatidial
formation. In the future, I plan to develop predictive active matter theories
including active nematic solids and active fluid/solid shells, which are broadly
applicable to biological systems, such as muscle development, and follicle
patterning.
Throughout, my aim is to understand the biomechanical principles of developmental
and evolutionary morphogenesis through close collaborations with experimentalists. |
